Appraisal of surgical resection of gallbladder cancer with special reference to lymph node dissection

Radical lymph node dissection in surgery for advanced gallbladder cancer is controversial. The purpose of this study is to evaluate the role of lymph node dissection based on the clinico-pathologic results. Seventy-three patients who underwent radical surgery including systematic dissection of the N...

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Bibliographic Details
Published in:Langenbeck's archives of surgery 2000-12, Vol.385 (8), p.509-514
Main Authors: Shimada, H, Endo, I, Fujii, Y, Kamiya, N, Masunari, H, Kunihiro, O, Tanaka, K, Misuta, K, Togo, S
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma - surgery
Cholecystectomy
Female
Gallbladder Neoplasms - mortality
Gallbladder Neoplasms - pathology
Gallbladder Neoplasms - surgery
Hepatectomy
Humans
Lymph Node Excision - standards
Lymphatic Metastasis - diagnosis
Male
Middle Aged
Neoplasm Staging
Prognosis
Retrospective Studies
Survival Analysis
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Summary:Radical lymph node dissection in surgery for advanced gallbladder cancer is controversial. The purpose of this study is to evaluate the role of lymph node dissection based on the clinico-pathologic results. Seventy-three patients who underwent radical surgery including systematic dissection of the N1+N2 region lymph node plus some of the para-aortic nodes were reviewed. pT1 patients had no lymph node metastasis, but pT2 and pT3/pT4 patients had lymph node metastasis at a rate of 50.0% (13/26) and 83.3% (25/30), respectively. As infiltration of the hepatoduodenal ligament (Binf) became severe, the rate and extent of lymph node metastasis increased. There were four 5-year survivors with lymph node involvement. The 5-year survival rates are 77.0% in pN0 cases and 27.3% in pN1 cases (P
ISSN:1435-2443
1435-2451
DOI:10.1007/s004230000163