Mast cells in an angiosarcoma complicating Xeroderma pigmentosum in a 13-year-old girl

A cutaneous angiosarcoma, a rare tumor that occurs almost exclusively in sunexposed skin of individuals older than 50 years, developed in an adolescent with Xeroderma pigmentosum (XP). As this is the second report of a child with angiosarcoma and XP, ultraviolet-induced DNA damage may be involved in...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2000-11, Vol.43 (5), p.900-902
Main Authors: Ludolph-Hauser, Dagmar, Thoma-Greber, Eva, Sander, Christian, Sommerhoff, Christian P., Röcken, Martin
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Dermatology
Female
Hemangiosarcoma - complications
Hemangiosarcoma - pathology
Humans
Mast Cells - pathology
Medical sciences
Pigmentary diseases of the skin
Skin - pathology
Skin Neoplasms - complications
Skin Neoplasms - pathology
Xeroderma Pigmentosum - complications
Xeroderma Pigmentosum - pathology
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Summary:A cutaneous angiosarcoma, a rare tumor that occurs almost exclusively in sunexposed skin of individuals older than 50 years, developed in an adolescent with Xeroderma pigmentosum (XP). As this is the second report of a child with angiosarcoma and XP, ultraviolet-induced DNA damage may be involved in the pathogenesis of this tumor. Strongly increased numbers of mast cells were found, particularly in the peripheral tumor area, which may reflect with the requirement of mast cells for the growth of vascular structures or a role for mast cells in the antitumor immune response. (J Am Acad Dermatol 2000;43:900-2.)
ISSN:0190-9622
1097-6787
DOI:10.1067/mjd.2000.101883