Urokinase stimulates differentiation of fibroblasts into myofibroblasts and their proliferation in damaged adventitia

Urokinase expression in the adventitia of rat common carotid artery increased on the 4th day after periadventitial damage. Periadventitial application of recombinant urokinase increased the area of the adventitia and the content of contractile and proliferating cells, while proteolytically inactive...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-05, Vol.129 (5), p.429-432
Main Authors: Plekhanova, O S, Volynskaya, E A, Kalinina, N I, Parfenova, E V
Format: Article
Language:English
Subjects:
Animals
Carotid Arteries - drug effects
Carotid Arteries - pathology
Carotid Arteries - physiopathology
Cell Differentiation - drug effects
Fibroblasts - drug effects
Fibroblasts - pathology
Male
Plasminogen Activators - pharmacology
Rats
Rats, Wistar
Recombinant Proteins - pharmacology
Urokinase-Type Plasminogen Activator - pharmacology
Vasoconstriction
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Summary:Urokinase expression in the adventitia of rat common carotid artery increased on the 4th day after periadventitial damage. Periadventitial application of recombinant urokinase increased the area of the adventitia and the content of contractile and proliferating cells, while proteolytically inactive recombinant urokinase was ineffective.
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02439792