Pre-clinical experimental studies of indomethacin-releasing copper intrauterine device

Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu2+ releasing amounts of both IUDs in vitro were observed. The results showed that the inhibiting action of the indomethacin-releasing cop...

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Bibliographic Details
Published in:Current medical science 2000, Vol.20 (3), p.249-252
Main Authors: Cao, L, Zhou, Y, Liu, Z, Du, Q, Li, W, Hu, Y
Format: Article
Language:English
Subjects:
Animals
Copper - metabolism
Endometrium - metabolism
Endometrium - pathology
Endothelin-1 - metabolism
Female
Indomethacin - administration & dosage
Intrauterine Devices, Copper
Prostaglandins - metabolism
Rabbits
Rats
Rats, Sprague-Dawley
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Summary:Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu2+ releasing amounts of both IUDs in vitro were observed. The results showed that the inhibiting action of the indomethacin-releasing copper IUD (FICu-IUD) on the PGI2 was stronger than that on the TXA2, the ratio of 6-keto-PGF1 alpha/TXB2 was reduced with the increase of the doses. There were significant differences between the groups. The FICu-IUD could inhibit the rising of the ET level and lighten the endometrial impairment caused by the FCu-IUD, and promote copper ion release. It was suggested that indomethacin released by FICu-IUD could effectively reduce abnormal uterine bleeding.
ISSN:0257-716X
2096-5230
2523-899X
DOI:10.1007/bf02887005