Effect of hyperinsulinemia on amino acid utilization in the ovine fetus

1  Perinatal Research Center and Departments of Pediatrics and 2  Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, 80262; and 3  Department of Surgery, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, 73190 We studied the effect...

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Published in:American journal of physiology: endocrinology and metabolism 2000-12, Vol.279 (6), p.E1294-E1304
Main Authors: Thureen, Patti J, Scheer, Bryan, Anderson, Susan M, Tooze, Janet A, Young, David A, Hay, William W., Jr
Format: Article
Language:English
Subjects:
Amino Acids - blood
Amino Acids - pharmacokinetics
Animals
Blood Glucose - metabolism
Electrolytes
Female
Fetus - metabolism
Gestational Age
Glucose
Glucose Clamp Technique
Hyperinsulinism - metabolism
Hypoglycemic Agents - blood
Hypoglycemic Agents - pharmacology
Insulin - blood
Insulin - pharmacology
Lysine - blood
Lysine - pharmacokinetics
Nitrogen - pharmacokinetics
Parenteral Nutrition Solutions
Pregnancy
Sheep
Solutions
Umbilical Arteries - physiology
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Summary:1  Perinatal Research Center and Departments of Pediatrics and 2  Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, 80262; and 3  Department of Surgery, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, 73190 We studied the effect of an acute 4-h period of hyperinsulinemia (H) on net utilization rates (AAUR net ) of 21 amino acids (AA) in 17 studies performed in 13 late-gestation fetal sheep by use of a novel fetal hyperinsulinemic-euglycemic-euaminoacidemic clamp. During H [84 ± 12 (SE) µU/ml H, 15 ± 2 µU/ml control (C), P  
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.2000.279.6.E1294