Histopathological and immunohistochemical study of lambs experimentally infected with Fasciola hepatica and Schistosoma bovis

The aim of this study was to investigate the cross-resistance between Fasciola hepatica and Schistosoma bovis in lambs assessing parasitologic, gross pathologic, histopathologic and immunohistochemical changes in liver and small intestine. Thirty Castellana breed lambs were divided into five compara...

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Bibliographic Details
Published in:Journal of veterinary medicine. Series B 2000-12, Vol.47 (10), p.763-773
Main Authors: Ferreras, M C, García-Iglesias, M J, Manga-González, M Y, Pérez-Martínez, C, Mizinska, Y, Ramajo, V, González-Lanza, M C, Escudero, A, García-Marín, J F
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Fascioliasis - parasitology
Fascioliasis - pathology
Fascioliasis - veterinary
Immunohistochemistry - veterinary
Intestine, Small - parasitology
Intestine, Small - pathology
Liver - parasitology
Liver - pathology
Schistosomiasis - parasitology
Schistosomiasis - pathology
Schistosomiasis - veterinary
Sheep
Sheep Diseases - parasitology
Sheep Diseases - pathology
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Summary:The aim of this study was to investigate the cross-resistance between Fasciola hepatica and Schistosoma bovis in lambs assessing parasitologic, gross pathologic, histopathologic and immunohistochemical changes in liver and small intestine. Thirty Castellana breed lambs were divided into five comparable groups and exposed to F. hepatical S. bovis (group F/S), S. bovis/F. hepatica (group S/F), S. bovis (group S) or F. hepatica (group F) and six unexposed lambs were used as non-infected controls (group C). Primary patent infection with F. hepatica induced a lower number of schistosome eggs and a higher number of lymphocytes in intestinal and liver schistosome egg-induced granulomas in group F/S than in the groups S/F and S, liver damage being mainly attributed to F. hepatica. S. bovis infection followed by challenge with F. hepatica particularly increased the severity of the most significant liver alterations (cholangiohepatitis by F. hepatica and mesoendophlebitis by S. bovis) and F. hepatica seemed not to have an influence on established S. bovis infection. In addition, immunohistochemical results suggested that the predominant local immune response in both double-infected groups was different, being mainly a cell-mediated immune response in group F/S and a mucosal response in group S/F.
ISSN:0931-1793
1439-0450
DOI:10.1046/j.1439-0450.2000.00410.x