New aspects of integrin signaling in cancer

Members of the integrin family of cell adhesion receptors influence several important aspects of cancer cell behavior, including motility and invasiveness, cell growth, and cell survival. Engagement of integrins with extracellular matrix (ECM) proteins can activate members of the Rho-family of small...

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Bibliographic Details
Published in:Seminars in cancer biology 2000-12, Vol.10 (6), p.407-414
Main Authors: Parise, Leslie V, Lee, Jung Weon, Juliano, R.L
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biological and medical sciences
Cell Movement
Dissemination
Humans
integrin / Rho-GTPase / apoptosis / PI-3-kinase / motility
Integrins - metabolism
Medical sciences
Neoplasms - metabolism
Phosphatidylinositol 3-Kinases - metabolism
rho GTP-Binding Proteins - metabolism
Rho protein
Signal Transduction - physiology
Tumor cell
Tumors
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Summary:Members of the integrin family of cell adhesion receptors influence several important aspects of cancer cell behavior, including motility and invasiveness, cell growth, and cell survival. Engagement of integrins with extracellular matrix (ECM) proteins can activate members of the Rho-family of small GTPases; conversely, Rho- and Ras-family proteins can influence the ability of integrins to bind their ligands. These events impinge on the control of cell motility, and ultimately on invasive and metastatic behavior. Integrin engagement with ECM also has important effects on cell survival, particularly for cells of epithelial origin. In some cases, specific integrins have selective effects on the efficiency of signal transduction in cell survival pathways.
ISSN:1044-579X
1096-3650
DOI:10.1006/scbi.2000.0337