Effect of mesodiencephalic modulation on small intestinal mucosa after massive blood loss in rats

Effect of mesodiencephalic modulation on small intestinal mucosa was studied in rats subjected to massive blood loss. Massive blood loss induced structural changes in intestinal epitheliocytes typical of tissue hypoxia: intraintestinal edema, mitochondrial alterations, and microcirculation disturban...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-11, Vol.130 (11), p.1058-1062
Main Authors: Titova, G P, Popova, T S, Poryadkov, L F, Solov'eva, G I, Fedichkina, T V, Tropskaya, N S, Grishchenko, A V
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Diencephalon - physiopathology
Electric Stimulation
Enterocytes - ultrastructure
Hemorrhage
Intestinal Mucosa - pathology
Intestinal Mucosa - ultrastructure
Intestine, Small - pathology
Intestine, Small - ultrastructure
Male
Rats
Rats, Wistar
Rodents
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Summary:Effect of mesodiencephalic modulation on small intestinal mucosa was studied in rats subjected to massive blood loss. Massive blood loss induced structural changes in intestinal epitheliocytes typical of tissue hypoxia: intraintestinal edema, mitochondrial alterations, and microcirculation disturbances. A single session of mesodiencephalic stimulation carried out 60 min after massive blood loss produced a pronounced adaptive effect, restored disturbed structure of the intestinal villi, and induced compensatory hypertrophy of the mitochondria. This suggests that mesodiencephalic modulation promotes normalization of intracellular energy metabolism, improves the absorption capacity of bordered enterocytes, and restores the disturbed intestinal barrier.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1002883315284