The human interferon α species and receptors

Interferon (IFN) was approved by the U.S. Food and Drug Administration on June 5, 1986. As the first biotherapeutic approved, IFN‐α paved the way for development of many other cytokines and growth factors. Nevertheless, we have just touched the surface of understanding the multitude of human IFNs. T...

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Bibliographic Details
Published in:Biopolymers 2000, Vol.55 (4), p.254-287
Main Author: Pestka, Sidney
Format: Article
Language:English
Subjects:
Animals
biotherapeutic
Chromatography, High Pressure Liquid
cytokines
genes
growth factors
human leucocyte
Humans
interferon
Interferon gamma Receptor
Interferon Type I - genetics
Interferon Type I - isolation & purification
Interferon-alpha - genetics
Interferon-alpha - isolation & purification
Interferon-alpha - pharmacology
Models, Biological
proteins
Receptor, Interferon alpha-beta
receptors
Receptors, Interferon - genetics
Receptors, Interferon - isolation & purification
Recombinant Proteins
Sequence Analysis, Protein
Signal Transduction
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Summary:Interferon (IFN) was approved by the U.S. Food and Drug Administration on June 5, 1986. As the first biotherapeutic approved, IFN‐α paved the way for development of many other cytokines and growth factors. Nevertheless, we have just touched the surface of understanding the multitude of human IFNs. This paper reviews the history of the purification of human leukocyte IFN and key aspects of our current state of knowledge of human interferon α genes, proteins, and receptors. © 2001 John Wiley & Sons, Inc. Biopolymers (Pept Sci) 55: 254–287, 2000
ISSN:0006-3525
1097-0282
DOI:10.1002/1097-0282(2000)55:4<254::AID-BIP1001>3.0.CO;2-1