Effect of Implanon ® use on selected parameters of thyroid and adrenal function

In this article, the effects of Implanon ® implant use on thyroid and adrenal function was compared with those of Norplant ® implants. In this 2-year open randomized study of 80 implant acceptors, we found that both implants may induce minimal changes in thyroid hormones and cortisol levels, possibl...

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Bibliographic Details
Published in:Contraception (Stoneham) 2000-11, Vol.62 (5), p.247-251
Main Authors: Biswas, Arijit, Viegas, Osborne A.C., Bennink, Herjan J.T.Coeling, Korver, Tjeerd, Ratnam, Shan S.
Format: Article
Language:English
Subjects:
3-Ketodesogestrel
Adrenal Cortex - drug effects
Adrenal Cortex - physiology
Biological and medical sciences
Birth control
Contraceptive Agents, Female - pharmacology
Desogestrel
Drug Implants
Etonogestrel
Female
Gynecology. Andrology. Obstetrics
Hormonal contraception
Humans
Hydrocortisone - blood
Implanon
Implants
Levonorgestrel - pharmacology
Longitudinal Studies
Medical sciences
Progestins
Random Allocation
Sex Hormone-Binding Globulin - drug effects
Sex Hormone-Binding Globulin - metabolism
Thyroid Gland - drug effects
Thyroid Gland - physiology
Thyroid Hormones - blood
Time Factors
Vinyl Compounds - pharmacology
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Summary:In this article, the effects of Implanon ® implant use on thyroid and adrenal function was compared with those of Norplant ® implants. In this 2-year open randomized study of 80 implant acceptors, we found that both implants may induce minimal changes in thyroid hormones and cortisol levels, possibly secondary to alterations in the respective binding globulins in the serum. These alterations in thyroid and adrenal function would have no clinical significance in healthy women. In the Norplant group, sex hormone-binding globulin levels decreased, whereas increased levels were found in the Implanon users at the end of 2 years. These findings lend support to the fact that etonogestrel, released from Implanon implants, is significantly less androgenic than levonorgestrel, released from the Norplant implants.
ISSN:0010-7824
1879-0518
DOI:10.1016/S0010-7824(00)00174-8