Sensitivity to curare in patients with upper and lower motor neurone dysfunction

Summary Sensitivity to the action of nondepolarising relaxants was compared in muscles of upper and lower limbs in four syringomyelic patients undergoing elective neurosurgical procedures. It was observed that muscles with signs of lower motor neurone dysfunction are supersensitive to the action of...

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Bibliographic Details
Published in:Anaesthesia 1991-11, Vol.46 (11), p.980-982
Main Authors: Fiacchino, F., Gemma, M., Bricchi, M., Giombini, S., Regi, B.
Format: Article
Language:English
Subjects:
Adult
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Female
Humans
Male
Medical sciences
Middle Aged
Motor Neuron Disease - etiology
Motor Neuron Disease - physiopathology
Muscles - drug effects
Muscles - innervation
Neuromuscular Junction - drug effects
Neuromuscular Nondepolarizing Agents
Neuromuscular relaxants
syringomyelia
Neuropharmacology
Pharmacology. Drug treatments
Syringomyelia - complications
Syringomyelia - surgery
Time Factors
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Summary:Summary Sensitivity to the action of nondepolarising relaxants was compared in muscles of upper and lower limbs in four syringomyelic patients undergoing elective neurosurgical procedures. It was observed that muscles with signs of lower motor neurone dysfunction are supersensitive to the action of nondepolarising relaxants. Terminal sprouting of motor axons and the occurrence of newly formed neuromuscular junctions may be responsible for a low synaptic efficacy and may explain the high sensitivity to factors that reduce the safety margin of neuromuscular transmission.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1991.tb09864.x