Delayed behavioral effects of beta-casomorphin-7 depend on age and gender of albino rat pups

Systemic administration of beta-casein heptapeptide beta-casomorphin-7 (YPFPGPI, 1 mg/kg daily) to 10-23-day-old albino rat pups produced delayed anxiolytic effects, which were more pronounced in female than in male rats. Experimental findings confirm our assumption on the important role of nutritio...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-11, Vol.130 (11), p.1031-1034
Main Authors: Dubynin, V A, Malinovskaya, I V, Ivleva, Y A, Andreeva, L A, Kamenskii, A A, Ashmarin, I P
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Age Factors
Animals
Anti-Anxiety Agents - metabolism
Anti-Anxiety Agents - pharmacology
Endorphins - metabolism
Endorphins - pharmacology
Escape Reaction - drug effects
Female
Male
Motor Activity - drug effects
Narcotics - metabolism
Peptide Fragments - metabolism
Peptide Fragments - pharmacology
Rats
Stress, Physiological
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Systemic administration of beta-casein heptapeptide beta-casomorphin-7 (YPFPGPI, 1 mg/kg daily) to 10-23-day-old albino rat pups produced delayed anxiolytic effects, which were more pronounced in female than in male rats. Experimental findings confirm our assumption on the important role of nutritional opioids in brain development in newborn mammals.
ISSN:0007-4888
DOI:10.1023/A:1002866911650