Bipolar Cells Use Kainate and AMPA Receptors to Filter Visual Information into Separate Channels

Unlike cone photoreceptors, whose light responses have a uniform time course, retinal ganglion cells are tuned to respond to different temporal components in a changing visual scene. The signals in a mammalian cone flow to three to five morphologically distinct “OFF” bipolar cells at a sign-conservi...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2000-12, Vol.28 (3), p.847-856
Main Author: DeVries, Steven H.
Format: Article
Language:English
Subjects:
Animals
Electric Stimulation
Fluorescent Dyes
In Vitro Techniques
Mammalia
Photic Stimulation
Reaction Time - physiology
Receptors, AMPA - metabolism
Receptors, Kainic Acid - metabolism
Retina - cytology
Retina - metabolism
Retinal Cone Photoreceptor Cells - cytology
Retinal Cone Photoreceptor Cells - metabolism
Retinal Ganglion Cells - cytology
Retinal Ganglion Cells - metabolism
Sciuridae
Synapses - metabolism
Synaptic Transmission - physiology
Vision, Ocular - physiology
Visual Pathways - cytology
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Summary:Unlike cone photoreceptors, whose light responses have a uniform time course, retinal ganglion cells are tuned to respond to different temporal components in a changing visual scene. The signals in a mammalian cone flow to three to five morphologically distinct “OFF” bipolar cells at a sign-conserving, glutamatergic synapse. By recording simultaneously from pairs of synaptically connected cones and OFF bipolar cells, I now show that each morphological type of OFF bipolar cell receives its signal through a different AMPA or kainate receptor. The characteristic rate at which each receptor recovers from desensitization divides the cone signal into temporal components. Temporal processing begins at the first synapse in the visual system.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(00)00158-6