Strategies of immunization against mucosal infections

The presence of secretory (S-) IgA in middle-ear fluid and localization of IgA-secreting cells in its mucosae suggest that the middle ear is an effector site of the mucosal immune system. Several strategies have been devised to induce potent, long-lasting, and recallable mucosal S-IgA antibodies, as...

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Bibliographic Details
Published in:Vaccine 2000-12, Vol.19, p.S122-S127
Main Authors: Russell, Michael W., Martin, Michael H., Wu, Hong-Yin, Hollingshead, Susan K., Moldoveanu, Zina, Mestecky, Jiri
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Bacterial Vaccines - immunology
Body Fluids - immunology
Ear, Middle - immunology
Forecasting
Goals
Humans
IgA antibodies
Immune Tolerance
Immunization - methods
Immunoglobulin A, Secretory - immunology
Immunoglobulin G - immunology
Lymphoid Tissue - immunology
Mucosal immunity
Mucosal vaccines
Mucous Membrane - immunology
Nasopharynx - immunology
Otitis Media - immunology
Otitis Media - prevention & control
Th1 Cells - immunology
Th2 Cells - immunology
Viral Vaccines - immunology
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Summary:The presence of secretory (S-) IgA in middle-ear fluid and localization of IgA-secreting cells in its mucosae suggest that the middle ear is an effector site of the mucosal immune system. Several strategies have been devised to induce potent, long-lasting, and recallable mucosal S-IgA antibodies, as well as circulating IgG antibodies and Th1- or Th2-type help, according to the most appropriate responses for a particular infection. Application of immunogens to inductive sites in the upper respiratory tract may be most effective for generating responses in the middle ear and nasopharynx for protection against the organisms responsible for otitis media.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(00)00290-5