The development of a catechol enzyme electrode and its possible use for the diagnosis and monitoring of neural crest tumours

A catechol enzyme electrode is described, in which a Clark-type oxygen electrode is coupled to immobilised polyphenol oxidase in albumin cross linked with glutaraldehyde on a dialysis membrane. Electrode calibration, response time, pH response profile, stability, detection limit and selectivity are...

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Bibliographic Details
Published in:Biosensors & bioelectronics 1991, Vol.6 (7), p.569-573
Main Authors: Tillyer, C.R., Gobin, P.T.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biosensing Techniques
biosensors
Calibration
catechol
Catechol Oxidase
catechol polyphenol oxidase
Catecholamines - urine
Central Nervous System Neoplasms - diagnosis
Central Nervous System Neoplasms - embryology
diagnosis
Electrochemistry
enzyme electrode
Enzymes, Immobilized
Equipment Design
Fundamental and applied biological sciences. Psychology
Humans
immobilized enzymes
Molecular biophysics
Monitoring, Physiologic - methods
Neural Crest
neuroblastoma
phaeochromocytoma
Physical chemistry in biology
polylphenol oxidase
role
tumours
urine
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Summary:A catechol enzyme electrode is described, in which a Clark-type oxygen electrode is coupled to immobilised polyphenol oxidase in albumin cross linked with glutaraldehyde on a dialysis membrane. Electrode calibration, response time, pH response profile, stability, detection limit and selectivity are evaluated and the feasibility of using the electrode for the measurement of catecholamines in the urine of patients with neural crest tumours is assessed.
ISSN:0956-5663
1873-4235
DOI:10.1016/0956-5663(91)80021-O