Relationship between leukotriene B4 and immunological parameters in rheumatoid synovial fluids

Leukotriene B4 (LTB4) was measured in synovial fluid from 20 patients with rheumatoid arthritis and 15 patients with osteoarthritis. The level of LTB4 was significantly higher in synovial fluid from rheumatoid arthritis patients as compared with synovial fluid from osteoarthritis patients. LTB4 leve...

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Bibliographic Details
Published in:Inflammation 1991-12, Vol.15 (6), p.497-503
Main Authors: NADJMEDINE AHMADZADEH, MASAO SHINGU, NOBUNAGA, M, TAWARA, T
Format: Article
Language:English
Subjects:
Adult
Aged
Antigen-Antibody Complex - metabolism
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - metabolism
Biological and medical sciences
Complement System Proteins - metabolism
Female
Fundamental and applied biological sciences. Psychology
Humans
Inflammation
Leukotriene B4 - metabolism
Male
Middle Aged
Molecular and cellular biology
Osteoarthritis - immunology
Osteoarthritis - metabolism
Synovial Fluid - immunology
Synovial Fluid - metabolism
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Summary:Leukotriene B4 (LTB4) was measured in synovial fluid from 20 patients with rheumatoid arthritis and 15 patients with osteoarthritis. The level of LTB4 was significantly higher in synovial fluid from rheumatoid arthritis patients as compared with synovial fluid from osteoarthritis patients. LTB4 levels also significantly correlated with cell numbers, rheumatoid factor, and immune complexes in synovial fluid from rheumatoid arthritis patients. There was an inverse correlation between LTB4 levels and complement components. The high-pressure liquid chromatography peak of immunoreactivity extracted from the synovial fluid occurred at a retention volume identical to that of authentic LTB4. These results suggest that the increased level of this mediator in synovial fluid may contribute to perpetuation of inflammation and tissue destruction in rheumatoid arthritis.
ISSN:0360-3997
1573-2576
DOI:10.1007/bf00923346