The JaICA-Genox Oxidative Stress Profile - An overview on the profiling technique in the oxidative stress assessment and management

• Published in: BioFactors (Oxford) 2000, Vol.13 (1-4), p.195-203
• Main Authors: Ochi, Hirotomo, Cheng, Rong-Zhu, Kantha, Sachi Sri, Takeuchi, Masao, Ramarathnam, Narasimhan
• Format: Article
• Language: English
• Subjects: age-related hormones; Aging; Animals; Animals, Laboratory; bio-markers; Biomarkers; cardiovascular disease risk factors; Cardiovascular Diseases - epidemiology; Disease; Free Radicals; Health Status; Hormones - blood; Humans; Oxidative Stress; profiling technique; Risk Factors; trace elements
• ISSN: 0951-6433; 1872-8081
• DOI: 10.1002/biof.5520130131

It is widely accepted that oxidative stress (OS) is a major causative factor for many of the age‐related dysfunctions and specific diseases. Since the oxidative stress state (OSS) of an individual depends on hereditary, dietary, and environmental factors, there is a large heterogeneity in the population that may be related to disease incidence and longevity. Hence there is a need to assess how well an individual is coping against OS. The Japan Institute for the Control of Aging (JaICA) and Genox have jointly developed a profiling technique to measure the “Oxidative Stress Profiles (JaICA‐Genox OSP)” of individuals and laboratory test animals. The JaICA‐Genox OSP consists of about 45 different assays measuring the levels of oxidative damage in lipids and nucleic acids, and the antioxidant defenses in the serum. In addition, several bio‐markers for cardiovascular disease risk are also measured, and assays to measure specific age‐ and sex‐related hormones in the serum and urine, and race elements in serum, urine, and drinking water are also undertaken. This overview discusses the designing of the JaICA‐Genox OSP and its application in the testing of human subjects.