Focal adhesions: structure and dynamics

Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell–extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a...

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Bibliographic Details
Published in:Biology of the Cell 2000-10, Vol.92 (7), p.477-494
Main Authors: Petit, Valérie, Thiery, Jean-Paul
Format: Article
Language:English
Subjects:
Cell Adhesion - physiology
Cytoskeletal Proteins - metabolism
extracellular matrix
focal adhesion
Focal Adhesions - chemistry
Focal Adhesions - metabolism
Humans
integrins
Integrins - metabolism
Membrane Proteins - metabolism
Models, Biological
Rho
rho GTP-Binding Proteins - metabolism
Signal Transduction - physiology
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Summary:Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell–extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the extracellular matrix components. Numerous structural and regulatory proteins assemble at the cytoplasmic face of focal adhesions in a Rho-dependent fashion.
ISSN:0248-4900
1768-322X
DOI:10.1016/S0248-4900(00)01101-1