Structural and functional properties of membrane and secreted IgD

More than 35 years ago, study of an unknown immunoglobulin (Ig) in the serum from a myeloma patient led to the discovery of IgD. Subsequently, the finding that it also exists as a membrane-bound Ig stimulated a large number of studies during the 70s. Then, the interest on IgD shrank, largely because...

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Bibliographic Details
Published in:Molecular Immunology 2000-10, Vol.37 (15), p.871-887
Main Authors: Preud'homme, Jean-Louis, Petit, Isabelle, Barra, Anne, Morel, Jean-Claude Lecron, Franck, Lelièvre, Eric
Format: Article
Language:English
Subjects:
Animals
B cell receptor
Cell Membrane - immunology
Cell Membrane - metabolism
Humans
IgD
Immunoglobulin D - biosynthesis
Immunoglobulin D - genetics
Immunoglobulin D - immunology
Immunoglobulin D - physiology
Receptors, Cell Surface - immunology
Receptors, Fc - immunology
Receptors, Immunologic - immunology
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Summary:More than 35 years ago, study of an unknown immunoglobulin (Ig) in the serum from a myeloma patient led to the discovery of IgD. Subsequently, the finding that it also exists as a membrane-bound Ig stimulated a large number of studies during the 70s. Then, the interest on IgD shrank, largely because of the lack of known function of secretory IgD (secIgD) and of a stagnating knowledge of the functions of surface IgD. In the recent years, very significant advances followed the tremendous accumulation of data on the physiology of the B cell receptor, of which IgD is the major component, on the role of secIgD in normal and diseased individuals. This review, which is focused on human IgD but integrates data in the mouse and other species when needed, summarizes present data on the structure, synthesis and functions of both membrane and secIgD, IgD receptors and the involvement of IgD in various diseases, especially the hyperIgD syndrome.
ISSN:0161-5890
1872-9142
DOI:10.1016/S0161-5890(01)00006-2