Coherence on Electroencephalography and Aberrant Functional Organisation of the Brain in Schizophrenic Patients During Activation Tasks

Thirty schizophrenic patients (20 medicated, 10 off medication) were compared with 30 normal control subjects matched for age, sex, handedness, and intelligence. During the performance of left-hemisphere cognitive activation tasks, normal subjects had significantly increased EEG alpha coherence in a...

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Bibliographic Details
Published in:British journal of psychiatry 1991-11, Vol.159 (5), p.636-644
Main Authors: Morrison-Stewart, Sandra L., Williamson, Peter C., Corning, William C., Kutcher, Stanley P., Merskey, Harold
Format: Article
Language:English
Subjects:
Arousal - physiology
Attention - physiology
Brain
Brain Mapping - instrumentation
Cerebral Cortex - physiopathology
Cognitive ability
Coherence
Dominance, Cerebral - physiology
Drugs
EEG
Electroencephalography
Electroencephalography - instrumentation
Female
Handedness
Hemispheric laterality
Humans
Intelligence
Male
Mental disorders
Mental Recall - physiology
Neurocognitive Disorders - diagnosis
Neurocognitive Disorders - physiopathology
Neurocognitive Disorders - psychology
Problem Solving - physiology
Psychiatric Status Rating Scales
Research subjects
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - physiopathology
Schizophrenic Psychology
Signal Processing, Computer-Assisted - instrumentation
Task performance
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Summary:Thirty schizophrenic patients (20 medicated, 10 off medication) were compared with 30 normal control subjects matched for age, sex, handedness, and intelligence. During the performance of left-hemisphere cognitive activation tasks, normal subjects had significantly increased EEG alpha coherence in areas related to left focal frontal sites, with decreases in temporal and posterior areas. Schizophrenic patients did not show the same degree of focal activation of left frontal areas. During the performance of right-hemisphere cognitive activation tasks, normal subjects and schizophrenic patients had similar patterns of right posterior increases in alpha coherence. Discriminant analyses were able to classify 81.4% of all subjects correctly. It is suggested that the findings indicate an aberrant functional organisation of the brain in schizophrenia, particularly affecting the left hemisphere.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.159.5.636