Apoptosis and airway inflammation in asthma

Asthma is a disease characterized by a chronic inflammation of the airways and by structural alterations of bronchial tissues, often referred to as airway remodelling. The development of chronic airway inflammation in asthma depends upon the continuous recruitment of inflammatory cells from the bloo...

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Bibliographic Details
Published in:Apoptosis (London) 2000-11, Vol.5 (5), p.473-485
Main Authors: Vignola, A M, Chiappara, G, Gagliardo, R, Gjomarkaj, M, Merendino, A, Siena, L, Bousquet, J, Bonsignore, G
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - immunology
Apoptosis - physiology
Asthma
Asthma - immunology
Asthma - pathology
Cells
Humans
Inflammation - immunology
Inflammation - pathology
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Summary:Asthma is a disease characterized by a chronic inflammation of the airways and by structural alterations of bronchial tissues, often referred to as airway remodelling. The development of chronic airway inflammation in asthma depends upon the continuous recruitment of inflammatory cells from the bloodstream towards the bronchial mucosa and by their subsequent activation. It is however increasingly accepted that mechanisms involved in the regulation of the survival and apoptosis of inflammatory cells may play a central role in the persistent inflammatory process characterizing this disease. Increased cellular recruitment and activation, enhanced cell survival and cell:cell interactions are therefore the key steps in the development of chronic airway inflammation in asthma, and represent the major causes for tissue damge, repair and remodelling.
ISSN:1360-8185
1573-675X
DOI:10.1023/A:1009661406440