Cyclosporine A prevents neurological deterioration of patients with SAH-A preliminary report

In the present study we found that the neurological outcome in patients anaesthetized for early clipping (up to 72 h after SAH) of a ruptured aneurysm and treated with cyclosporine A was significantly better than the neurological state of control patients without immuno-suppressive treatment. The re...

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Bibliographic Details
Published in:Acta neurochirurgica 1991-01, Vol.112 (1-2), p.25-27
Main Authors: RYBA, M, PASTUSZKO, M, IWANSKA, K, BIDZINSKI, J, DZIEWIECKI, C
Format: Article
Language:English
Subjects:
Adult
Autoimmune Diseases - prevention & control
Biological and medical sciences
Cyclosporine - therapeutic use
Female
Humans
Immunomodulators
Intracranial Aneurysm - surgery
Ischemic Attack, Transient - prevention & control
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Postoperative Complications - prevention & control
Rupture, Spontaneous
Subarachnoid Hemorrhage - surgery
Treatment Outcome
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Summary:In the present study we found that the neurological outcome in patients anaesthetized for early clipping (up to 72 h after SAH) of a ruptured aneurysm and treated with cyclosporine A was significantly better than the neurological state of control patients without immuno-suppressive treatment. The results justify the presumption that auto-immune reactions are involved in the deterioration of the postoperative neurological state of patients with SAH after rupture of an intracranial aneurysm. Supplementing a standard surgical and pharmacological treatment with cyclosporine A seems to reduce the undesirable neurological consequences of the immunologically, induced vascular disturbance after SAH.
ISSN:0001-6268
0942-0940
DOI:10.1007/BF01402450