Speciation of gold(III)-L-histidine complex: a multi-instrumental approach

The formation and structure of gold (III)-L-histidine complex was investigated with the use of carbon (13C) and proton (1H) nuclear magnetic resonance (NMR), infrared (IR) spectroscopy, capillary electrophoresis (CE), capillary electrophoresis-inductively coupled plasma-mass spectroscopy (CE-ICP-MS)...

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Bibliographic Details
Published in:Journal of environmental monitoring 2000-01, Vol.2 (4), p.355-359
Main Authors: Cuadrado, J A, Zhang, W, Hang, W, Majidi, V
Format: Article
Language:English
Subjects:
Chemical Precipitation
Gold - chemistry
Histidine - chemistry
Hydrogen-Ion Concentration
Ligands
Magnetic Resonance Spectroscopy
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Spectroscopy, Fourier Transform Infrared
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Summary:The formation and structure of gold (III)-L-histidine complex was investigated with the use of carbon (13C) and proton (1H) nuclear magnetic resonance (NMR), infrared (IR) spectroscopy, capillary electrophoresis (CE), capillary electrophoresis-inductively coupled plasma-mass spectroscopy (CE-ICP-MS), X-ray fluorescence spectroscopy (XRF), matrix-assisted laser desorption/ionization (MALDI), and laser desorption mass spectroscopy (LDMS). It was found that two L-histidine molecules and one gold ion slowly form a complex in acidic solution. Each L-histidine molecule provided two nitrogen ligands; one was the alpha-amino group and the other from the imidazole ring. The Au(III)-bis-L-histidine complex precipitates after deprotonation of the free carboxylic group, resulting in an increase in the solution acidity. Determination of the exact sequence of events and the identity of the complex was a comprehensive instrumental analysis problem involving the above techniques.
ISSN:1464-0325
1464-0333
DOI:10.1039/b000085j