Management of locally advanced rectal cancer

The treatment of rectal cancer typically involves a multidisciplinary approach. A minority of patients will have tumors that are full thickness, involve adjacent structures, or have metastatic disease to regional lymph nodes. The combination of adjuvant therapy and surgical resection is the mainstay...

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Bibliographic Details
Published in:Surgical oncology 2000-12, Vol.9 (4), p.193-204
Main Authors: Sasson, Aaron R., Sigurdson, Elin R.
Format: Article
Language:English
Subjects:
Adjuvant therapy
Advanced rectal cancer
Chemotherapy, Adjuvant
Humans
Lymph Node Excision
Mesorectal excision
Pelvic Exenteration
Postoperative Complications - epidemiology
Proctocolectomy, Restorative
Radiotherapy, Adjuvant
Rectal Neoplasms - drug therapy
Rectal Neoplasms - radiotherapy
Rectal Neoplasms - surgery
Rectal Neoplasms - therapy
Rectum - surgery
Survival Rate
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Summary:The treatment of rectal cancer typically involves a multidisciplinary approach. A minority of patients will have tumors that are full thickness, involve adjacent structures, or have metastatic disease to regional lymph nodes. The combination of adjuvant therapy and surgical resection is the mainstay of treatment for locally advanced carcinoma of the rectum. This article will review the role of adjuvant chemotherapy and radiotherapy in patients with high risk tumors. The operative considerations in advanced rectal cancers will be reviewed. In particular, the role of mesorectal excision and exenterative surgery will be discussed.
ISSN:0960-7404
1879-3320
DOI:10.1016/S0960-7404(01)00012-3