Nodal T Cell Blast Crisis in Chronic Myeloid Leukemia

We report the case of a 54 year old male with an original diagnosis of chronic myeloid leukemia (CML) who developed a nodal T cell blast crisis (BC) while he was in a complete hematological remission (CR). We describe the clinical presentation and the histological, immunophenotypic and molecular cha...

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Bibliographic Details
Published in:Leukemia & lymphoma 2000, Vol.39 (3-4), p.435-440
Main Authors: Lucero, G., Birman, V., Colimiodio, E., Bertinetti, C. M., Kotliar, N., Murolo, P., Irusta, O., Klimovsky, J., Koziner, B.
Format: Article
Language:English
Subjects:
Blast Crisis - etiology
Blast Crisis - pathology
CD3 Complex - analysis
Cell Transformation, Neoplastic
CML-blast crisis
Diagnosis, Differential
Humans
Immunophenotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology
Lymph Nodes - pathology
Lymphoma, T-Cell - diagnosis
Lymphoma, T-Cell - etiology
Lymphoma, T-Cell - genetics
Male
Middle Aged
Philadelphia Chromosome
T cell non-Hodgkin's lymphoma
TCR gene rearrangements
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Summary:We report the case of a 54 year old male with an original diagnosis of chronic myeloid leukemia (CML) who developed a nodal T cell blast crisis (BC) while he was in a complete hematological remission (CR). We describe the clinical presentation and the histological, immunophenotypic and molecular characterization of the lymph node blast cells. Our case, together with other rare similar reports in the literature, argue that a T cell nodal blast crisis of CML resembles the presentation of a T-cell non-Hodgkin's lymphoma.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428190009065845