EFFECT OF ADRENALINE ON EXTRADURAL ANAESTHESIA, PLASMA LIGNOCAINE CONCENTRATIONS AND THE FETO-PLACENTAL UNIT DURING ELECTIVE CAESAREAN SECTION

Extradural anaesthesia was induced with either 2% lignocaine or 2% lignocaine with adrenaline 1:200000 in 20 patients undergoing elective Caesarean section. With the adrenaline-containing solution, a smaller dose of lignocaine was required to produce an adequate block and the lignocaine concentratio...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1991-12, Vol.67 (6), p.683-689
Main Authors: MCLINTIC, A.J., DANSKIN, F.H., REID, J.A., THORBURN, J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anaesthesia: obstetric
Anaesthetic techniques: extradural
Anesthesia, Epidural
Anesthesia, Obstetrical
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Cesarean Section
Epinephrine - pharmacology
Female
Fetus - blood supply
Fetus - drug effects
Heart Rate, Fetal - drug effects
Humans
Lidocaine - blood
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Placenta
Placenta - blood supply
Placenta - drug effects
Pregnancy
Regional Blood Flow - drug effects
umbilical blood flow
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Summary:Extradural anaesthesia was induced with either 2% lignocaine or 2% lignocaine with adrenaline 1:200000 in 20 patients undergoing elective Caesarean section. With the adrenaline-containing solution, a smaller dose of lignocaine was required to produce an adequate block and the lignocaine concentrations in both mother and neonate were significantly smaller compared with the plain solution. Arterial pressures were less in the adrenaline group, but there was no difference in umbilical flow velocity waveform, fetal heart rate or fetal outcome. Neither feto-placental circulation nor fetal outcome were affected adversely by episodes of hypotension or the ephedrine used for treatment.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/67.6.683