Surveillance of methicillin-resistant Staphylococcus aureus (MRSA) and Enterobacteriaceae producing extended-spectrum β-lactamase (ESBLE) in Northern France: a five-year multicentre incidence study

• Published in: The Journal of hospital infection 2002-10, Vol.52 (2), p.107-113
• Main Authors: Albertini, M T, Benoit, C, Berardi, L, Berrouane, Y, Boisivon, A, Cahen, P, Cattoen, C, Costa, Y, Darchis, P, Delière, E, Demontrond, D, Eb, F, Golliot, F, Grise, G, Harel, A, Koeck, J L, Lepennec, M P, Malbrunot, C, Marcollin, M, Maugat, S, Nouvellon, M, Pangon, B, Ricouart, S, Roussel-Delvallez, M, Vachée, A, Carbonne, Anne, Marty, Lawrence, Jarlier, Vincent
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - therapeutic use; Antibiotic resistance, epidemiology, prevention, surveillance, nosocomial; Bacteremia - drug therapy; Bacteremia - epidemiology; Bacterial diseases; beta-Lactamases - metabolism; Biological and medical sciences; Cross Infection - drug therapy; Cross Infection - epidemiology; Enterobacteriaceae; Epidemiology. Vaccinations; France - epidemiology; General aspects; Human bacterial diseases; Humans; Incidence; Infectious diseases; Klebsiella Infections - drug therapy; Klebsiella Infections - epidemiology; Klebsiella pneumoniae - isolation & purification; Medical sciences; Methicillin Resistance; Population Surveillance; Staphylococcal Infections - drug therapy; Staphylococcal Infections - epidemiology; Staphylococcal infections, streptococcal infections, pneumococcal infections; Staphylococcus aureus - drug effects; Staphylococcus aureus - isolation & purification
• ISSN: 0195-6701; 1532-2939
• DOI: 10.1053/jhin.2002.1286

In order to measure the incidence of methicillin-resistant Staphylococcus aureus (MRSA) and of Enterobacteriaceae producing extended-spectrum β-lactamase (ESBLE), and to evaluate the impact of the national guidelines for multidrug-resistant bacteria (MDRB) prevention in hospitals of Northern France, a multicentre survey was conducted for three months every year starting in 1996, in volunteer hospital laboratories. All clinical specimens positive for MRSA and ESBLE were prospectively surveyed. During the five-year surveillance period, the overall proportion of MRSA was 38.4% in the 28 534 strains of S. aureus, and that of ESBLE was 11.4% in the 6121 strains of Klebsiella pneumoniae and 47.7% in the 2353 strains of Enterobacter aerogenes. The overall incidence rates of clinical specimens positive for MRSA, ESBL- K. pneumoniae and E. aerogenes were 0.84, 0.05 and 0.12/1000 hospital-days (HD), respectively. In the 23 hospitals that participated in the survey every year, the proportion and incidence of MRSA increased from 35.6 to 41.0% and from 0.71 to 0.96/1000 HD ( P