Effect of N-acetylcysteine on colitis induced by acetic acid in rats

(1) To verify the proposed role of reactive oxygen species (ROS) in ulcerative colitis, the effect of an antioxidant N-acetylcysteine (NAC) was studied in acetic acid (AA)-induced colonic inflammation. (2) Depending on the dose used, NAC administered intracolonically was found to reduce the extent o...

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Bibliographic Details
Published in:General pharmacology 2000-08, Vol.35 (2), p.77-81
Main Authors: Nosál'ová, Viera, C̆erná, Silvia, Bauer, Viktor
Format: Article
Language:English
Subjects:
Acetic Acid
Acetylcysteine - therapeutic use
Animals
Antioxidant
Biological and medical sciences
Colitis - drug therapy
Digestive system
Dose-Response Relationship, Drug
General and cellular metabolism. Vitamins
Glutathione
Glutathione - analysis
Inflammation
Male
Medical sciences
Peroxidase - metabolism
Pharmacology. Drug treatments
Rats
Rats, Wistar
Reactive Oxygen Species
Vascular permeability
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Summary:(1) To verify the proposed role of reactive oxygen species (ROS) in ulcerative colitis, the effect of an antioxidant N-acetylcysteine (NAC) was studied in acetic acid (AA)-induced colonic inflammation. (2) Depending on the dose used, NAC administered intracolonically was found to reduce the extent of colonic damage, along with a decrease in myeloperoxidase (MPO) activity, colonic wet weight and wet/dry weight ratio. (3) NAC attenuated the enhanced vascular permeability and prevented the depletion of colonic reduced glutathione (GSH) caused by AA administration. (4) The findings indicate that NAC may prove beneficial in the treatment of colitis.
ISSN:0306-3623
1879-0011
DOI:10.1016/S0306-3623(01)00094-5