Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF‐7 human breast cancer cell

Although the pharmacology and clinical application of water extracts of Ganoderma lucidum have been extensively documented, little is known regarding its alcohol extract. In the present study, the anti‐tumor effect of an alcohol extract of Ganoderma lucidum was investigated using MCF‐7 cells. We fou...

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Bibliographic Details
Published in:International journal of cancer 2002-11, Vol.102 (3), p.250-253
Main Authors: Hu, Hongbo, Ahn, Nam‐Shik, Yang, Xinlin, Lee, Yong‐Soon, Kang, Kyung‐Sun
Format: Article
Language:English
Subjects:
Alcohols - pharmacology
Apoptosis
Blotting, Western
breast cancer
Breast Neoplasms - drug therapy
Caspase 7
Caspases - metabolism
cell cycle
Cell Cycle Proteins
Cell Division
Cyclin D1 - metabolism
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinases - metabolism
DNA-Binding Proteins
Dose-Response Relationship, Drug
Down-Regulation
E2F Transcription Factors
ganoderma lucidum
Genes, p53
Humans
Plant Extracts - therapeutic use
Poly(ADP-ribose) Polymerases - metabolism
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras) - metabolism
Reishi - metabolism
Time Factors
Transcription Factors - metabolism
Tumor Cells, Cultured
Up-Regulation
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Summary:Although the pharmacology and clinical application of water extracts of Ganoderma lucidum have been extensively documented, little is known regarding its alcohol extract. In the present study, the anti‐tumor effect of an alcohol extract of Ganoderma lucidum was investigated using MCF‐7 cells. We found that the alcohol extract of Ganoderma lucidum inhibited cell proliferation in a dose‐ and time‐dependent manner, which might be mediated through up‐regulation of p21/Waf1 and down‐regulation of cyclin D1. Furthermore, this compound can directly induce apoptosis in MCF‐7 cells, which might be mediated through up‐regulation of a pro‐apoptotic Bax protein and not by the immune system. Our findings suggest that there are multiple mechanisms underlying the anti‐tumor effects of Ganoderma lucidum. © 2002 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.10707