Peritoneal fluid, endometriosis, and ciliary beat frequency in the human fallopian tube

Endometriosis and infertility are known to be associated, but it is unclear whether endometriosis causes infertility. We used contrast analogue enhancement to study the effect of peritoneal fluid from women with early stage endometriosis on the ciliary beat frequency of human fallopian tube epitheli...

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Bibliographic Details
Published in:The Lancet (British edition) 2002-10, Vol.360 (9341), p.1221-1222, Article 1221
Main Authors: Lyons, Rachel A, Djahanbakhch, Ovrang, Saridogan, Ertan, Naftalin, Alan A, Mahmood, Tariq, Weekes, Anthony, Chenoy, Rashna
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Ascitic Fluid
Biological and medical sciences
Case-Control Studies
Cilia
Endometriosis
Endometriosis - complications
Endometriosis - physiopathology
Fallopian Tubes
Female
Female genital diseases
Fertility
Gynecology. Andrology. Obstetrics
Humans
Incubation
Infertility
Infertility, Female - etiology
Infertility, Female - physiopathology
Medical disorders
Medical sciences
Middle Aged
Non tumoral diseases
Obstetrics
Reproductive system
Time Factors
Women
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Summary:Endometriosis and infertility are known to be associated, but it is unclear whether endometriosis causes infertility. We used contrast analogue enhancement to study the effect of peritoneal fluid from women with early stage endometriosis on the ciliary beat frequency of human fallopian tube epithelium. We obtained peritoneal fluid from six women with early stage endometriosis and from six fertile women with no evidence of endometriosis to use as controls. Fallopian tubes from hysterectomy specimens were collected from 17 women. The difference in ciliary beat frequency between fallopian tubes exposed to peritoneal fluids of women with and without endometriosis increased with the duration of incubation (mean difference at 24 h 1-35 Hz, 95% Cl 0·94–1·75, p=0·01). At 24 h, ciliary beat frequency was significantly lower in the incubations with peritonal fluid from women with endometriosis than controls (4·29 [0·15] vs 5·64 Hz [0·15], respectively, p=0·001). Impairment of ciliary action in women with endometriosis might reduce fertility.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(02)11247-5