Bioactive Constituents from Iryanthera megistophylla

Activity-guided fractionation of the 95% ethanol extract from the stem bark of Iryanthera megistophylla led to the isolation of two new compounds, named megislignan [2,3-dimethyl-4-(4-methoxyphenyl)-6-hydroxynaphthalene] (1) and megislactone [(2R,3R,4R)-3-hydroxy-4-methyl-2-(hexacos-17-enyl)butanoli...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-10, Vol.65 (10), p.1412-1416
Main Authors: MING, Dong Sheng, LóPEZ, Andrés, HILLHOUSE, Brian J., FRENCH, Christopher J., HUDSON, Jim B., TOWERS, G. H. Neil
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biological Factors - chemistry
Biological Factors - isolation & purification
General pharmacology
Medical sciences
Myristicaceae - chemistry
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Spectrum Analysis
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Summary:Activity-guided fractionation of the 95% ethanol extract from the stem bark of Iryanthera megistophylla led to the isolation of two new compounds, named megislignan [2,3-dimethyl-4-(4-methoxyphenyl)-6-hydroxynaphthalene] (1) and megislactone [(2R,3R,4R)-3-hydroxy-4-methyl-2-(hexacos-17-enyl)butanolide] (2), along with seven known compounds, grandinolide (3), iryantherin K (4), iryantherin L (5), cinchonain I b (6), cinchonain I a (7), procyanidin B-2 (8), and cinchonain IIa (9). The structures of the new compounds were elucidated by spectral data interpretation. Isolates were evaluated for their antibacterial, antifungal, antiviral, and antiacetylcholinesterase activities.
ISSN:0163-3864
1520-6025
DOI:10.1021/np020169l