Hypocomplementemic urticarial vasculitis: Report of a 12-year-old girl with systemic lupus erythematosus

Urticarial vasculitis, a form of leukocytoclastic vasculitis involving the postcapillary venules, is classified as a type III hypersensitivity reaction and has been associated with connective tissue disease. The lesions resemble urticaria and typically persist for more than 24 hours. Urticarial vasc...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2002-11, Vol.47 (5), p.S273-S274
Main Authors: DeAmicis, Tracy, Mofid, Mona Z., Cohen, Bernard, Nousari, Hossein C.
Format: Article
Language:English
Subjects:
Acute Disease
Anti-Inflammatory Agents - therapeutic use
Biological and medical sciences
Child
Complement System Proteins - deficiency
Dermatology
Female
Humans
Lupus Vasculitis, Central Nervous System - drug therapy
Lupus Vasculitis, Central Nervous System - immunology
Medical sciences
Methylprednisolone - therapeutic use
Pancreatitis - immunology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Skin involvement in other diseases. Miscellaneous. General aspects
Urticaria - drug therapy
Urticaria - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Urticarial vasculitis, a form of leukocytoclastic vasculitis involving the postcapillary venules, is classified as a type III hypersensitivity reaction and has been associated with connective tissue disease. The lesions resemble urticaria and typically persist for more than 24 hours. Urticarial vasculitis usually affects young women, and the diagnosis is confirmed at histologic examination. Patients with urticarial vasculitis can be divided into 2 types—those with normal complement levels and those with hypocomplementemic urticarial vasculitis (HUV). Patients with normocomplementemic urticarial vasculitis have a milder course than do patients with HUV, a condition that has a strong association with systemic lupus erythematosus. Angioedema, ocular inflammation, obstructive lung disease, and glomerulonephritis are commonly associated with HUV. We describe the case of a girl with systemic lupus erythematosus and HUV who also had pancreatitis, hypothyroidism, and elevated levels of antiphospholipid antibodies. (J Am Acad Dermatol 2002;47:S273-4.)
ISSN:0190-9622
1097-6787
DOI:10.1067/mjd.2002.108586