Relationship between reactive nitrogen intermediates and total immunoglobulin E, soluble CD21 and soluble CD23: comparison between cerebral malaria and nonsevere malaria

• Published in: Parasite immunology 2002-08, Vol.24 (8), p.395-399
• Main Authors: Nacher, Mathieu, Singhasivanon, Pratap, Kaewkungwal, Jaranit, Silachamroon, Udomsak, Treeprasertsuk, Sombat, Tosukhowong, Thanawat, Vannaphan, Suparp, Looareesuwan, Sornchai
• Format: Article
• Language: English
• Subjects: Animals; Case-Control Studies; cerebral malaria; Epstein–Barr virus; Humans; IgE; Immunoglobulin E - analysis; Logistic Models; Malaria - diagnosis; Malaria - immunology; Malaria, Cerebral - diagnosis; Malaria, Cerebral - immunology; Malaria, Cerebral - metabolism; Multivariate Analysis; nitric oxide; Odds Ratio; Plasmodium falciparum - cytology; Plasmodium falciparum - pathogenicity; Reactive Nitrogen Species - analysis; Receptors, Complement 3d - analysis; Receptors, IgE - analysis; Solubility; soluble CD21; soluble CD23
• ISSN: 0141-9838; 1365-3024
• DOI: 10.1046/j.1365-3024.2002.00481.x

Summary To search for evidence of a protective role of the CD23/NO pathway against cerebral malaria, concentrations of reactive nitrogen intermediates (RNI) and sCD21, total immunoglobulin (Ig)E and sCD23 were compared between 17 cases of cerebral malaria and 33 controls. The geometric mean of sCD23 concentration was higher among cerebral malaria cases than among controls (optical density 2643/1495, P = 0·01). The ratio between sCD21 and sCD23 was significantly lower in cerebral malaria cases than in controls (0·67 ± 0·02 versus 0·77 ± 0·02, respectively, P = 0·009). Multiple linear regression analysis showed that, among cerebral malaria cases, there was a clear correlation between RNI and both IgE (P = 0·007) and sCD21 (P