Histology of joint inflammation induced in rats by cell wall fragments of the anaerobic intestinal bacterium Eubacterium aerofaciens

To study the arthropathic properties of human intestinal bacteria, cell wall fragments (CWF) of the anaerobic bowel bacterium Eubacterium aerofaciens were injected intraperitoneally (i.p.) in arthritis-susceptible Lewis rats. Rat paw joints were subsequently studied for histopathological changes. A...

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Bibliographic Details
Published in:Rheumatology international 1991-01, Vol.11 (4-5), p.203-208
Main Authors: SEVERIJNEN, A. J, VAN KLEEF, R, GRANDIA, A. A, VAN DER KWAST, T. H, HAZENBERG, M. P
Format: Article
Language:English
Subjects:
Animals
Arthritis, Infectious - etiology
Arthritis, Infectious - pathology
Arthritis, Rheumatoid - etiology
Arthritis, Rheumatoid - microbiology
Arthritis, Rheumatoid - pathology
Bacterial Infections - etiology
Bacterial Infections - pathology
Biological and medical sciences
Cell Membrane - physiology
Cell Membrane - ultrastructure
Chronic Disease
Disease Models, Animal
Diseases of the osteoarticular system
Eubacterium - physiology
Eubacterium - ultrastructure
Female
Hindlimb
Inflammatory joint diseases
Injections, Intraperitoneal
Intestines - microbiology
Medical sciences
Rats
Rats, Inbred Lew
Time Factors
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Summary:To study the arthropathic properties of human intestinal bacteria, cell wall fragments (CWF) of the anaerobic bowel bacterium Eubacterium aerofaciens were injected intraperitoneally (i.p.) in arthritis-susceptible Lewis rats. Rat paw joints were subsequently studied for histopathological changes. A persisting synovitis accompanied by marginal erosions of cartilage and bone and a marked periosteal apposition of new bone tissue were the main features of the polyarthritis induced. These results are discussed in relation to streptococcal cell wall induced arthritis and compared with histopathological findings in rheumatoid arthritis (RA) in man.
ISSN:0172-8172
1437-160X
DOI:10.1007/BF00332563