Acute effects of antidepressant drugs on long-term potentiation (LTP) in rat hippocampal slices

The actions of three clinically effective antidepressant drugs with different pharmacological profiles were investigated in the CA1 area of rat hippocampal slices. Imipramine and (+) or (-)-oxaprotiline had negligible effects on population spikes evoked by stratum radiatum stimulation, but reduced p...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1991-07, Vol.344 (1), p.79-83
Main Authors: BIRNSTIEL, S, HAAS, H. L
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Animals
Antidepressive Agents - metabolism
Antidepressive Agents - pharmacology
Biological and medical sciences
Calcium - pharmacology
Culture Media
Electric Stimulation
Female
Hippocampus - anatomy & histology
Hippocampus - drug effects
Hippocampus - physiology
Imipramine - pharmacology
Magnesium - pharmacology
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred Strains
Receptors, N-Methyl-D-Aspartate - drug effects
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Summary:The actions of three clinically effective antidepressant drugs with different pharmacological profiles were investigated in the CA1 area of rat hippocampal slices. Imipramine and (+) or (-)-oxaprotiline had negligible effects on population spikes evoked by stratum radiatum stimulation, but reduced postsynaptic excitability in low Ca high Mg medium after an exposure of more than 15 min. Imipramine and (+)-oxaprotiline at 10 mumol/l enhanced long-term potentiation (LTP) when a lower stimulation strength was applied while (+)-oxaprotiline reduced LTP when a higher stimulus amplitude was used to evoke population spikes. (-)-oxaprotiline (levoprotiline) had a similar effect which was, however, not significant in either stimulation paradigm at the P less than 0.05 level. Imipramine actions were also studied on epileptiform discharges in Mg(2+)-free medium: a facilitation-inhibition sequence with a slow time course was seen with 50 mumol/l but no effect with 10 mumol/l. An involvement of N-methyl-D-aspartate (NMDA)-receptors in acute actions of antidepressants is unlikely but long-term potentiation in the hippocampus is modulated by these drugs.
ISSN:0028-1298
1432-1912
DOI:10.1007/BF00167385