Maporal Viral Infection in the Syrian Golden Hamster: A Model of Hantavirus Pulmonary Syndrome

Hantavirus pulmonary syndrome (HPS) is a severe and often fatal rodent-borne zoonosis. Maporal (MAP) virus is a newly discovered hantavirus that originally was isolated from an arboreal rice rat captured in central Venezuela. The results of this study indicate that MAP virus in the Syrian golden ham...

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Bibliographic Details
Published in:The Journal of infectious diseases 2002-11, Vol.186 (10), p.1390-1395
Main Authors: Milazzo, Mary Louise, Eyzaguirre, Eduardo J., Molina, Claudia P., Fulhorst, Charles F.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antigens
Biological and medical sciences
Cricetinae
Disease Models, Animal
Female
Hantavirus
Hantavirus - classification
Hantavirus Infections - pathology
Hantavirus Infections - physiopathology
Hantavirus pulmonary syndrome
Hantavirus Pulmonary Syndrome - pathology
Hantavirus Pulmonary Syndrome - physiopathology
Human viral diseases
Infectious diseases
Kidneys
Liver
Lungs
Major Articles
Medical sciences
Memory interference
Mesocricetus
Pulmonary edema
Tropical medicine
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Viruses
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Summary:Hantavirus pulmonary syndrome (HPS) is a severe and often fatal rodent-borne zoonosis. Maporal (MAP) virus is a newly discovered hantavirus that originally was isolated from an arboreal rice rat captured in central Venezuela. The results of this study indicate that MAP virus in the Syrian golden hamster (Mesocricetus auratus) can cause a disease that is clinically and pathologically remarkably similar to HPS. The similarities include the time course of clinical disease, presence of virus-specific IgG at the onset of clinical disease, subacute pneumonitis, rapid onset of diffuse alveolar edema in the absence of necrosis, hepatic-portal triaditis, mononuclear-cellular infiltrate in lung and liver, widespread distribution of hantaviral antigen in endothelial cells of the microvasculature of lung and other tissues, and variable lethality. These similarities suggest that the MAP virus–hamster system is a useful model for studies of the pathogenesis of HPS and for the evaluation of potential therapeutic agents
ISSN:0022-1899
1537-6613
DOI:10.1086/344735