Oral Administration of a Novel Chymase Inhibitor, NK3201, Prevents Peritoneal Adhesion Formation in Hamsters

We investigated the preventive effect of an orally active chymase inhibitor, NK3201 (2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide), on the adhesion formation in a hamster experimental model. Hamsters were administered orally...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of pharmacology 2002, Vol.90(1), pp.94-96
Main Authors: Okamoto, Yukiko, Takai, Shinji, Miyazaki, Mizuo
Format: Article
Language:English
Subjects:
Acetamides - pharmacology
Adhesion
Administration, Oral
Animals
Cell Adhesion - drug effects
Cell Adhesion - physiology
Chymase
Chymases
Cricetinae
Enzyme Inhibitors - pharmacology
Female
Mast cell
Mast Cells - drug effects
Mast Cells - enzymology
Mesocricetus
Peritoneal Cavity - physiology
Pyrimidines - pharmacology
Serine Endopeptidases - metabolism
Uterus - drug effects
Uterus - enzymology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the preventive effect of an orally active chymase inhibitor, NK3201 (2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide), on the adhesion formation in a hamster experimental model. Hamsters were administered orally once daily with 30 mg/kg of NK3201 or placebo from 3 days before uterus scraping to 7 days after it. A significant increase of chymase activity in the injured uterus was reduced by treatment with NK3201. The score of adhesion formations in the chymase inhibitor-treated group was significantly decreased in comparison with that in the placebo-treated group (P
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.90.94