Ethanol protects against lysophosphatidylcholine-induced uncoupling of cardiac cell pairs

Moderate alcohol consumption is related to a reduction in cardiovascular deaths. Lysophosphatidylcholine (LPC) produces arrhythmias similar to those induced by ischemia most likely due to its uncoupling properties. We assessed effects of LPC in the presence of ethanol in cardiac myocyte pairs using...

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Bibliographic Details
Published in:Pflügers Archiv 2002-10, Vol.445 (1), p.55-59
Main Author: Daleau, Pascal
Format: Article
Language:English
Subjects:
Animals
Electric Conductivity
Ethanol
Ethanol - pharmacology
Guinea Pigs
Intracellular Membranes - physiology
Ischemia
Kinetics
Lysophosphatidylcholines - pharmacology
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - physiology
Patch-Clamp Techniques
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Summary:Moderate alcohol consumption is related to a reduction in cardiovascular deaths. Lysophosphatidylcholine (LPC) produces arrhythmias similar to those induced by ischemia most likely due to its uncoupling properties. We assessed effects of LPC in the presence of ethanol in cardiac myocyte pairs using the double whole-cell voltage-clamp technique. Ethanol 11, 22 and 44 mmol.l(-1) did not change junctional conductance for up to 25 min but postponed the time for total uncoupling induced by 20 micromol.l(-1) LPC from 11.3+/-3.0 min ( n=4), respectively, to 16.0+/-0.5 ( n=3; P=0.05), 20.5+/-1.9 min ( n=4; P
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-002-0896-8