Molecular and morphological characterization of Echinococcus granulosus of human and animal origin in Iran

Iran is an important endemic focus of cystic hydatid disease (CHD) where several species of intermediate host are commonly infected with Echinococcus granulosus. Isolates of E. granulosus were collected from humans and other animals from different geographical areas of Iran and characterized using b...

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Bibliographic Details
Published in:Parasitology 2002-10, Vol.125 (4), p.367-373
Main Authors: FASIHI HARANDI, M., HOBBS, R. P., ADAMS, P. J., MOBEDI, I., MORGAN-RYAN, U. M., THOMPSON, R. C. A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Camelus - parasitology
Cattle
cystic hydatid disease
Echinococcosis - epidemiology
Echinococcosis - parasitology
Echinococcus - anatomy & histology
Echinococcus - classification
Echinococcus - genetics
Echinococcus - isolation & purification
Echinococcus granulosus
Fundamental and applied biological sciences. Psychology
Genes, Helminth - genetics
Genetics of eukaryotes. Biological and molecular evolution
Genotype
Genotypes
Goats - parasitology
Humans
Invertebrata
Iran
Iran - epidemiology
Logistic Models
molecular characterization
morphology
Mouth - anatomy & histology
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Population genetics, reproduction patterns
Sheep
Sheep - parasitology
strains
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Summary:Iran is an important endemic focus of cystic hydatid disease (CHD) where several species of intermediate host are commonly infected with Echinococcus granulosus. Isolates of E. granulosus were collected from humans and other animals from different geographical areas of Iran and characterized using both DNA (PCR-RFLP of ITS1) and morphological criteria (metacestode rostellar hook dimensions). The sheep and camel strains/genotypes were shown to occur in Iran. The sheep strain was shown to be the most common genotype of E. granulosus affecting sheep, cattle, goats and occasionally camels. The majority of camels were infected with the camel genotype as were 3 of 33 human cases. This is the first time that cases of CHD in humans have been identified in an area where a transmission cycle for the camel genotype exists. In addition, the camel genotype was found to cause infection in both sheep and cattle. Results also demonstrated that both sheep and camel strains can be readily differentiated on the basis of hook morphology alone.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182002002172