The effect of intravenous clonidine on the forearm circulation

Summary The effect of two doses of clonidine on forearm blood flow was compared with an inert treatment using mercury strain gauge venous occlusive plethysmography. In the clonidine treated groups, forearm blood flow was unaffected in the resting state, but decreased sharply with tracheal intubation...

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Bibliographic Details
Published in:Anaesthesia 1991-12, Vol.46 (12), p.1013-1015
Main Authors: CARABINE, U. A., WRIGHT, P. M. C., KEARNEY, E., HOWE, J. P., MOORE, J.
Format: Article
Language:English
Subjects:
Adult
Anesthesia, General
Antihypertensive agents
Biological and medical sciences
Cardiovascular system
Clonidine - administration & dosage
Clonidine - pharmacology
Forearm - blood supply
Humans
Injections, Intravenous
Intubation, Intratracheal
Measurement techniques
venous occlusive plethysmography
Medical sciences
Pharmacology. Drug treatments
Pharmacology
clonidine
Regional Blood Flow - drug effects
Vascular Resistance - drug effects
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Summary:Summary The effect of two doses of clonidine on forearm blood flow was compared with an inert treatment using mercury strain gauge venous occlusive plethysmography. In the clonidine treated groups, forearm blood flow was unaffected in the resting state, but decreased sharply with tracheal intubation. In the saline group, blood flow increased with intubation. Forearm vascular resistance increased in the clonidine treated groups, but decreased in the saline group. These results suggest that clonidine has a peripheral action in anaesthetised normotensive individuals, and is not a purely centrally acting drug.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1991.tb09911.x