CYP2C9 allelic variants: ethnic distribution and functional significance

Cytochrome P-450 (CYP) 2C9 CYP2C9 is a polymorphically expressed enzyme responsible for the metabolism of several clinically important drugs, some with a low therapeutic index. This review summarizes the structure–function relationship of the CYP2C9 promoter and coding regions, known polymorphisms,...

Full description

Saved in:
Bibliographic Details
Published in:Advanced drug delivery reviews 2002-11, Vol.54 (10), p.1257-1270
Main Authors: Xie, Hong-Guang, Prasad, Harish C, Kim, Richard B, Stein, C.Michael
Format: Article
Language:English
Subjects:
African Continental Ancestry Group - genetics
Allelic variants
Aryl Hydrocarbon Hydroxylases - genetics
Asian Continental Ancestry Group - genetics
CYP2C9
Cytochrome P-450 CYP2C9
Ethnic variability
European Continental Ancestry Group - genetics
Gene Frequency - genetics
Genotyping
Humans
Meta-analysis
Pharmacogenetics
Polymorphism
Polymorphism, Genetic
Promoter Regions, Genetic
Substrate Specificity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cytochrome P-450 (CYP) 2C9 CYP2C9 is a polymorphically expressed enzyme responsible for the metabolism of several clinically important drugs, some with a low therapeutic index. This review summarizes the structure–function relationship of the CYP2C9 promoter and coding regions, known polymorphisms, the functional significance of various CYP2C9 alleles in vitro and in vivo, and their population frequencies. In addition, possible molecular mechanisms underlying ethnic variability in the metabolism of CYP2C9 substrate drugs are discussed.
ISSN:0169-409X
1872-8294
DOI:10.1016/S0169-409X(02)00076-5