Phosphorus metabolite changes in temporal lobes of subjects with schizotypal personality disorder

Using in vivo 31P magnetic resonance spectroscopy, phosphorus metabolite levels were measured in the temporal lobes of 11 neuroleptic-free subjects with schizotypal personality disorder (SPD) and 20 age-matched healthy subjects. SPD subjects showed smaller amounts of phosphomonoesters in the left te...

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Bibliographic Details
Published in:Schizophrenia research 2002-12, Vol.58 (2), p.201-203
Main Authors: Fukuzako, Hiroshi, Kodama, Satoshi, Fukuzako, Tsuyoshi
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Female
Functional Laterality - physiology
Humans
Magnetic Resonance Spectroscopy
Male
Medical sciences
Personality disorders
Phosphorus - metabolism
Phosphorus metabolites
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Schizotypal personality disorder
Schizotypal Personality Disorder - metabolism
Temporal lobe
Temporal Lobe - metabolism
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Summary:Using in vivo 31P magnetic resonance spectroscopy, phosphorus metabolite levels were measured in the temporal lobes of 11 neuroleptic-free subjects with schizotypal personality disorder (SPD) and 20 age-matched healthy subjects. SPD subjects showed smaller amounts of phosphomonoesters in the left temporal lobe than healthy subjects. Membrane phospholipid abnormalities in the left temporal lobe may be a common pathophysiologic feature in schizophrenia spectrum disorders.
ISSN:0920-9964
1573-2509
DOI:10.1016/S0920-9964(02)00157-3