Viable but Nonculturable Salmonella Species Recovery and Systemic Infection in Morphine-Treated Mice

In vivo recovery and pathogenicity of Salmonella enterica serovar Oranienburg that became viable but nonculturable (VNC) in food were examined. VNC cells were completely eliminated in normal mice but caused systemic bacteremia and were subsequently lethal to morphine-treated mice. Therefore, morphin...

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Bibliographic Details
Published in:The Journal of infectious diseases 2002-11, Vol.186 (10), p.1526-1529
Main Authors: Asakura, Hiroshi, Watarai, Masahisa, Shirahata, Toshikazu, Makino, Sou-ichi
Format: Article
Language:English
Subjects:
Agriculture
Animal models
Animals
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Concise Communications
Cultured cells
Disease Models, Animal
Female
Foodborne illnesses
Human bacterial diseases
Infections
Infectious diseases
Medical sciences
Mice
Mice, Inbred BALB C
Morphine
Morphine - pharmacology
Pathogens
Salmonella
Salmonella enterica - drug effects
Salmonella enterica - pathogenicity
Salmonella Infections - microbiology
Salmonella Infections - mortality
Squid
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Summary:In vivo recovery and pathogenicity of Salmonella enterica serovar Oranienburg that became viable but nonculturable (VNC) in food were examined. VNC cells were completely eliminated in normal mice but caused systemic bacteremia and were subsequently lethal to morphine-treated mice. Therefore, morphine-treated mice might be a useful bioassay for VNC Salmonella species in implicated food items
ISSN:0022-1899
1537-6613
DOI:10.1086/344353