Apparent beneficial effects of tamoxifen on bone mineral content in patients with breast cancer: preliminary study

Eight postmenopausal women undergoing adjuvant treatment with tamoxifen (20 mg/day) for breast cancer had baseline pretreatment, and 6- and 12-month post-treatment dual-photon determinations of vertebral bone mineral content (BMC). BMC measured at 6 and 12 months increased over baseline in all subje...

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Bibliographic Details
Published in:Osteoporosis international 1991-10, Vol.2 (1), p.39-41
Main Authors: Ryan, W G, Wolter, J, Bagdade, J D
Format: Article
Language:English
Subjects:
Aged
Bone Density - drug effects
Breast Neoplasms - drug therapy
Female
Humans
Menopause
Middle Aged
Tamoxifen - therapeutic use
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Summary:Eight postmenopausal women undergoing adjuvant treatment with tamoxifen (20 mg/day) for breast cancer had baseline pretreatment, and 6- and 12-month post-treatment dual-photon determinations of vertebral bone mineral content (BMC). BMC measured at 6 and 12 months increased over baseline in all subjects. These observations imply that women treated with tamoxifen may retain rather than surrender the protective effect of estrogen against osteoporosis.
ISSN:0937-941X
1433-2965
DOI:10.1007/BF01627077