Iridoids: A New Class of Leishmanicidal Agents from Nyctanthes arbortristis

Iridoid glucosides (arbortristosides A [I], B [2], C [3], and 6beta-hydroxy-loganin [4] isolated from the traditional plant Nyctanthes arbortristis show antileishmanial activity in both in vitro (against amastigotes in macrophage cultures) and in vivo (in hamsters) test systems.

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1991-07, Vol.54 (4), p.1102-1104
Main Authors: Tandon, J. S, Srivastava, Vandita, Guru, P. Y
Format: Article
Language:English
Subjects:
Animals
antiprotozoaire
antiprotozoal agents
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - isolation & purification
Biological and medical sciences
Cricetinae
General pharmacology
glicosidos
glucoside
glucosides
Glucosides - isolation & purification
Glucosides - pharmacology
glucosidos
glycoside
glycosides
hamster
hamsters
leishmania
leishmania donovani
Leishmania donovani - drug effects
Leishmaniasis, Visceral - drug therapy
Male
Medical sciences
medicamentos contra protozoarios
medicinal properties
Mesocricetus
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal
propiedades medicinales
propriete pharmacologique
Pyrans - isolation & purification
Pyrans - pharmacology
Sigmodontinae
verbenaceae
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Description
Summary:Iridoid glucosides (arbortristosides A [I], B [2], C [3], and 6beta-hydroxy-loganin [4] isolated from the traditional plant Nyctanthes arbortristis show antileishmanial activity in both in vitro (against amastigotes in macrophage cultures) and in vivo (in hamsters) test systems.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50076a030