Soluble methane monooxygenase: activation of dioxygen and methane

The mechanisms by which soluble methane monooxygenase uses dioxygen to convert methane selectively to methanol have come into sharp focus. Diverse techniques have clarified subtle details about each step in the reaction, from binding and activating dioxygen, to hydroxylation of alkanes and other sub...

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Bibliographic Details
Published in:Current Opinion in Chemical Biology 2002-10, Vol.6 (5), p.568-576
Main Authors: Kopp, Daniel A, Lippard, Stephen J
Format: Article
Language:English
Subjects:
Alkanes - chemistry
Binding Sites
Catalysis
CH bond activation
dioxygen activation
Electron Transport
Hydroxylation
Kinetics
Methane - chemistry
methane monooxygenase
Methylococcaceae - enzymology
Models, Molecular
Non-heme diiron
Oxygen - chemistry
Oxygenases - chemistry
Oxygenases - metabolism
probe structures
Protein Binding
Quantum Theory
Solubility
Substrate Specificity
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Summary:The mechanisms by which soluble methane monooxygenase uses dioxygen to convert methane selectively to methanol have come into sharp focus. Diverse techniques have clarified subtle details about each step in the reaction, from binding and activating dioxygen, to hydroxylation of alkanes and other substrates, to the electron transfer events required to complete the catalytic cycle. Soluble methane monooxygenase selectivity oxidizes methane to methanol. Recent advances in understanding how this remarkable reaction occurs are discussed.
ISSN:1367-5931
1879-0402
DOI:10.1016/S1367-5931(02)00366-6