Aggregate data meta-analysis with time-to-event outcomes

In a meta‐analysis of randomized controlled trials with time‐to‐event outcomes, an aggregate data approach may be required for some or all included studies. Variation in the reporting of survival analyses in journals suggests that no single method for extracting the log(hazard ratio) estimate will s...

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Bibliographic Details
Published in:Statistics in medicine 2002-11, Vol.21 (22), p.3337-3351
Main Authors: Williamson, Paula R., Smith, Catrin Tudur, Hutton, Jane L., Marson, Anthony G.
Format: Article
Language:English
Subjects:
aggregate data
Anticonvulsants - therapeutic use
Biological and medical sciences
Carbamazepine - therapeutic use
Cerebral Palsy - mortality
Cohort Studies
Computerized, statistical medical data processing and models in biomedicine
Epilepsy - drug therapy
Epilepsy - prevention & control
Female
Humans
Life Tables
Male
Medical sciences
Medical statistics
meta-analysis
Meta-Analysis as Topic
number at risk
Randomized Controlled Trials as Topic - methods
Survival Analysis
survival curve
time-to-event outcome
Valproic Acid - therapeutic use
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Summary:In a meta‐analysis of randomized controlled trials with time‐to‐event outcomes, an aggregate data approach may be required for some or all included studies. Variation in the reporting of survival analyses in journals suggests that no single method for extracting the log(hazard ratio) estimate will suffice. Methods are described which improve upon a previously proposed method for estimating the log(HR) from survival curves. These methods extend to life‐tables. In the situation where the treatment effect varies over time and the trials in the meta‐analysis have different lengths of follow‐up, heterogeneity may be evident. In order to assess whether the hazard ratio changes with time, several tests are proposed and compared. A cohort study comparing life expectancy of males and females with cerebral palsy and a systematic review of five trials comparing two anti‐epileptic drugs, carbamazepine and sodium valproate, are used for illustration. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0277-6715
1097-0258
DOI:10.1002/sim.1303