Elevated levels of Factor XI are associated with cardiovascular disease in women

Coronary artery disease (CAD) continues to be the most frequent cause of death among women in the United States. Although elevated levels of clotting factors have been associated with CAD, few of these studies have been performed in women. Elevated levels of Factor XI have previously been associated...

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Bibliographic Details
Published in:Thrombosis research 2002-07, Vol.107 (1), p.55-60
Main Authors: Berliner, Jennifer I, Rybicki, Anne C, Kaplan, Robert C, Monrad, E.Scott, Freeman, Ruth, Billett, Henny H
Format: Article
Language:English
Subjects:
Age Factors
Aged
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Case-Control Studies
Cholesterol - blood
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - etiology
Coronary heart disease
Factor XI
Factor XI - analysis
Female
Heart
Hematologic and hematopoietic diseases
Humans
Male
Medical sciences
Middle Aged
Platelet diseases and coagulopathies
Risk Factors
Thrombophilia
Thrombosis - blood
Thrombosis - etiology
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Summary:Coronary artery disease (CAD) continues to be the most frequent cause of death among women in the United States. Although elevated levels of clotting factors have been associated with CAD, few of these studies have been performed in women. Elevated levels of Factor XI have previously been associated with venous thrombosis, but little is known about its effect on arterial thrombosis. We selected women referred for cardiac catheterization who were found to have either normal coronaries or evidence of severe CAD and compared levels of homocysteine, anticardiolipin IgG/IgM antibodies, fibrinogen, platelet count, Factor VII, Factor VIII and Factor XI. Women with severe CAD had significantly higher levels of Factor XI than those without CAD (128% vs. 82%, p6.18 mmol/l (>239 mg/dl) compared with normocholesteremic women and was also higher in the upper tertile of age, but even when adjusted for these, the association remained significant. This initial study suggests that Factor XI may be an important parameter in arterial as well as venous thrombosis.
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(02)00190-1