Nogo on the Go

Growth inhibition in the central nervous system (CNS) is a major barrier to axon regeneration. Recent findings indicate that three distinct myelin proteins, myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte-myelin glycoprotein (OMgp), inhibit axon growth by binding a common receptor, t...

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Bibliographic Details
Published in:Neuron 2002-10, Vol.36 (3), p.345-348
Main Authors: McKerracher, Lisa, Winton, Matthew J
Format: Article
Language:English
Subjects:
Animals
Axons - metabolism
Central Nervous System - growth & development
Central Nervous System - metabolism
Chromatography
GPI-Linked Proteins
Humans
Kinases
Molecular weight
Myelin Proteins - metabolism
Myelin Sheath - metabolism
Myelin-Associated Glycoprotein - metabolism
Myelin-Oligodendrocyte Glycoprotein
Nerve Regeneration - physiology
Nogo Proteins
Nogo Receptor 1
Proteins
Receptors, Cell Surface - metabolism
Rodents
Spinal cord injuries
Studies
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Description
Summary:Growth inhibition in the central nervous system (CNS) is a major barrier to axon regeneration. Recent findings indicate that three distinct myelin proteins, myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte-myelin glycoprotein (OMgp), inhibit axon growth by binding a common receptor, the Nogo66 receptor (NgR), and likely converge on a common signaling cascade.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(02)01018-8