The histomorphologic sequence of dural repair : observations in the canine model

This study was undertaken to investigate the histopathologic events of the dural reparative process. Uniform 2-mm dural defects were created in adult beagles, repaired, and then examined in a 6-week period. Primary fibroblastic bridging of the durotomy was not seen until Postoperative Day 6, and it...

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Bibliographic Details
Published in:Spine (Philadelphia, Pa. 1976) Pa. 1976), 1991-01, Vol.16 (8S), p.S319-S323
Main Authors: CAIN, J. E, LAUERMAN, W. C, ROSENTHAL, H. G, BROOM, M. J, JACOBS, R. R
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cerebrospinal fluid. Spinal cord. Spinal roots. Spinal nerves
Dogs
Dura Mater - injuries
Dura Mater - pathology
Dura Mater - physiopathology
Medical sciences
Neurosurgery
Postoperative Complications - pathology
Postoperative Complications - physiopathology
Pressure
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue Adhesions - pathology
Tissue Adhesions - physiopathology
Wound Healing - physiology
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Summary:This study was undertaken to investigate the histopathologic events of the dural reparative process. Uniform 2-mm dural defects were created in adult beagles, repaired, and then examined in a 6-week period. Primary fibroblastic bridging of the durotomy was not seen until Postoperative Day 6, and it was not until Postoperative Day 10 that ablation of this defect was uniformly seen. Cerebrospinal fluid egress through the dural defects was prevented in the vast majority of cases by the formation of an internal patch composed of proliferative elements of pia and arachnoid mater.
ISSN:0362-2436
1528-1159
DOI:10.1097/00007632-199108001-00002